David Hearst
Tuesday May 20, 2003
The Guardian
Viruses and bacteria could be genetically engineered to evade the
human immune system, to create a more effective biological weapon, a
leading researcher into bio-weapons said yesterday.
In the past 30 years biotechnology has been revolutionised by
molecular biology and genetic engineering. These techniques, used to
control infectious diseases, can also be used to create more
effective biological weapons.
Speaking at the conference on the future of weaponry, Professor
Kathryn Nixdorff, of the University of Darmstadt, said that
dangerous micro-organisms had already been produced inadvertently
during attempts to modify vaccines and viruses.
Russian researchers had created a strain of anthrax bacilli
capable of evading immune mechanisms: hamsters injected with the
engineered strain were not protected by the usual anthrax vaccine.
Australian researchers trying to develop a vaccine to prevent
pregnancy in mice stumbled upon a new and more virulent form of
mousepox virus which inhibited the production of a class of
lymphocytes needed to combat the infection.
Although humans were not susceptible to infection by mousepox
virus there was concern that the human pox virus could be similarly
manipulated to make it more deadly.
There were several ways in which modifying micro-organisms had
potential military use. Bugs could be given a resistance to
antibiotics, they could be made more resistant to the environment
and thus longer lasting, and they could be made more lethal.
But she dismissed the suggestion that information gained from the
sequencing of the human genome could be used to create a biological
weapon specific to a particular racial or ethnic group.
"At present this seems unlikely for several reasons," she said.
"It has been pointed out in several reports that races do not exist
from a genetic perspective; there is generally more genetic
variation within groups than between groups.
"Indeed, it has been suggested that a re-examination of the race
concept is due."
There was concern that the genome sequence information could be
misused. A research team was reported to have built the polio virus
from sequence information publicly available, but this was a
relatively simple virus and the feat could not be readily repeated
with more complex ones.