INTRODUCTION TO THE CITIZENS PETITION ON STATINS
Peter H. Langsjoen, MD
medical profession has, after more than 30 years of excellent
propaganda, successfully created the wholly iatrogenic -
"pseudo-disease" dubbed "hypercholesterolemia" and the associated
malady "cholesterol neurosis". After decades of dismal failure to cure
this "disease" of numbers with low fat diets and a host of cholesterol
lowering drugs, the medical profession stumbled upon the magic bullet,
the cure for this dreaded artificial disease - statins (HMG-CoA
reductase inhibitors). First released on the US market in 1987,
statins have rapidly grown into one of the most widely prescribed
class of drugs in history. Statins do three things:
block the body's ability to make cholesterol, thus lowering the blood
level of cholesterol, thereby curing cholesterol neurosis. Doctors and
patients equally neurotic have immediate gratification. The "evil"
high cholesterol has been dramatically lowered and the future is
bright and promising. So far...so good.
Unrelated to their cholesterol lowering, statins have been found to
have anti-inflammatory, plaque-stabilizing properties which have a
slight benefit in coronary heart disease.
Statins kill people - lots of people - and they wound many, many more.
All patients taking statins become depleted in Coenzyme Q10 (CoQ10),
eventually - those patients who start with a relatively low CoQ10
levels (the elderly and patients with heart failure) begin to manifest
signs/symptoms of CoQ10 deficiency relatively rapidly - in 6 to 12
months. Younger, healthier people who's only "illness" is the
non-illness "hypercholesterolemia" can tolerate statins for several
years before getting into trouble with fatigue, muscle weakness and
soreness (usually with normal muscle enzyme CPK tests) and most
ominously - heart failure.
practice of 17 years in Tyler, Texas, I have seen a frightening
increase in heart failure secondary to statin usage, "statin
cardiomyopathy". Over the past five years, statins have become more
potent, are being prescribed in higher doses, and are being used with
reckless abandon in the elderly and in patients with "normal"
cholesterol levels. We are in the midst of a CHF epidemic in the US
with a dramatic increase over the past decade. Are we causing this
epidemic through our zealous use of statins? In large part I think the
answer is yes. We are now in a position to witness the unfolding of
the greatest medical tragedy of all time - never before in history has
the medical establishment knowingly (Merck & Co., Inc. has two
1990 patents combining CoQ10 with statins to prevent CoQ10 depletion
and attendant side effects) created a life threatening nutrient
deficiency in millions of otherwise healthy people, only to then sit
back with arrogance and horrific irresponsibility and watch to see
what happens - as I see two to three new statin cardiomyopathies per
week in my practice, I cannot help but view my once great profession
with a mixture of sorrow and contempt.
CoQ10 depletion is the topic of a recent petition to the FDA
requesting that this drug/nutrient interaction be identified in a
black box warning as part of statin package insert information. A
comprehensive review of animal and human trials addressing this issue
has been submitted to the FDA as a supporting document. We, of course,
do not expect any response from the FDA, but 10 years from now when
the full extent of statin toxicity becomes painfully evident, at least
we can, in good conscience, know that we tried and who knows,
sometimes small sparks may spread in dry grass.
Drugs And The Depletion Of Coenzyme Q10: A Review Of Human And Animal
By Peter H. Langsjoen, MD
Petition: Needed - A Change In The Labeling Of All Statin Drugs