DENVER
- Everything is falling into place for the federal government to
start inoculating health workers to protect them against a possible
bioterror attack with smallpox, top health officials said Thursday.
The smallpox vaccine sailed through initial safety tests. Vaccine maker
Acambis of Cambridge, Mass., is on track to deliver 209 million doses to the
government, some by end of this year, the company's chief scientist said.
The federal government has set up an elaborate safety system for expected
dangerous side effects. They could include some deaths and thousands of
serious illnesses, according to the Centers for Disease Control and
Prevention.
Now all that's needed is a go-ahead from President Bush.
The president must decide how many health and emergency workers will get
the vaccine as a bioterror preparedness measure, as well as whether the
inoculations will be offered to the general public.
Health officials are ready to vaccinate soon after Bush decides, said Dr.
James Hughes, director of the CDC's National Center for Infectious Diseases.
In order to get vaccinations done quickly, the CDC will use old stockpiled
vaccines - made from scraping the skin of cows deliberately infected -
before shifting to the new cloned vaccine being produced by Acambis, he
said.
"There are a lot of preparations that have been done," Hughes said
Thursday at the American Society of Tropical Medicine and Hygiene's
convention in Denver.
A special CDC advisory committee recommends voluntary vaccinations for
500,000 health workers who would have the first contact with smallpox
victims. After that, up to 10 million other health workers, police,
firefighters and paramedics should get the vaccine, and then it should be
offered to the general public on a voluntary basis, top health officials
recommended to the president this fall.
Smallpox is one of the deadliest and most contagious diseases in human
history, killing about 3 out of 10 people who contract it. It was eradicated
worldwide 25 years ago. Small samples of the virus are stored in two labs,
one in the United States and one in Russia. However, there have been reports
that some countries or terrorists may have smallpox cultures that could be
made into a weapon.
Officials fear Iraq has such cultures, but there is no evidence of that.
There is no controversy over the federal plan to quickly vaccinate people
after a smallpox attack. The debate is over vaccinating people before an
outbreak, because it involves using a live vaccine that contains a weak but
related pox virus called vaccinia.
Acambis chief scientific officer Thomas Monath said a test of 30 people
using the vaccine found little difference between it and the old one
commonly used before the disease was eradicated. There were no major side
effects, although everyone vaccinated had skin reactions, two-thirds felt
headaches, and one-quarter developed muscle pains. Early tests in mice and
monkeys show that the new vaccine may produce fewer side effects in the
nervous system, a nagging problem with the old one.
The CDC calculates that out of every million people vaccinated, the
vaccine would kill two people, give 52 people life-threatening illnesses and
infect 1,000 people with serious but not life-threatening reactions.
That's no worse than what happened with the old vaccine, which was given
throughout the United States in the 1950s and `60s to schoolchildren until
smallpox's eradication made vaccinations unnecessary. A new study said that
36.4 percent of the people vaccinated in the past missed school, work or
other events because of side effects from their inoculations, said
epidemiologist Scott Campbell with the
CDC's newly formed Smallpox Immunization Safety System. Normal mild bad
reactions include sore arms, fever and body aches.