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IMPORTANT NOTICE:

Sometime before the end of the year, this website will be going full archive unless I can get support for maintaining the daily RSS feeds.  That means there will be no updating, although you will still be able to access the articles archived here.  Regardless, you also will no longer be able to deduct any donations you make because Vaccination News will no longer be a non-profit.  (Because I got so few donations in the past, we lost our “public charity” status some years ago and had to become a foundation, which costs much more to file with the IRS, and I am no longer willing to subsidize those costs.)

 

All the best,

Sandy Gottstein

President, Vaccination News

President, Vaccination News, A Non-Profit Corporation

Credible estimates of vaccine adverse reaction under



Connaught testimony to the Institute of Medicine

James Froeschle, Connaught Laboratories, Swiftwater, Pennsylvania Dr. Froeschle gave information about adverse events following diphtheria and tetanus toxoids (DT) that had been reported to Connaught.  From a comparison of spontaneous reports with postmarketing surveillance data, the company estimates about a 50-fold underreporting of adverse events in the passive reporting system.  The distribution of types of events, however, was found to be approximately the same; in both cases, the majority of reported events were local reactions or fever.  The company has seen a marked decrease in adverse event reports since the inception of VAERS late in 1991, because physicians are now requested to send reports directly to the VAERS contractor.

David Kessler statement in JAMA - June 2, 1993,vol.269, No.21, p.2785

Although the FDA receives many adverse event reports, these probably represent only a fraction of the serious adverse events encountered by providers.  A recent review article found that between 3% and 11% of hospital admissions could be attributed to adverse drug reactions.  Only about 1% of serious events are reported to the FDA, according to one study.

The reporting sensitivities of two passive surveillance systems for Vaccine Adverse Events

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