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Asthma and vaccines literature search

xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns="http://www.w3.org/TR/REC-html40"> Asthma and vaccines literature search

 

Some journal articles from a Medline search relevant to the

probable association between asthma and vaccines. What I found

most interesting is that it has been shown conclusively that

pertussis vaccine directly causes an asthmatic condition in

mice. You sure don't hear THAT discussed much! Note that this

search was done several years ago, so it doesn't include the

latest research, but you'll get the point!

 

Only the abstracts are included when available, otherwise

just identifying information for anyone who cares to look

up the article. I've put "[***]" next to the articles I

find to be most interesting.

 

Most of these articles pertain to direct causation of

asthma; I didn't include the line of research consistent

with the Hygiene Hypothesis which shows that vaccinated

children and those who do not get measles (not necessarily

the same children!) are much more likely to suffer from asthma.

 

Dave Foster

 

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JAMA 1994 Aug 24-31;272(8):592-3 Pertussis vaccination and asthma:

is there a link?

 

Odent MR, Culpin EE, Kimmel T Comment on: JAMA 1994 Mar

23-30;271(12):929-31

 

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Allergy 1980 Jun;35(4):291-6 Effect of Bordetella pertussis vaccination

in mice and the isolated tracheal response to isoprenaline. [***]

 

Bartell TE, Busse WW

 

The administration of Bordetella pertussis vaccine to mice has been

associated with the development of an impaired beta-adrenoceptor

responsiveness and in many respects has resembled human asthma. Trachea

(n = 12) were isolated from Swiss-Webster mice 5 days following the

intraperitoneal administration of 2 x 10(9) B. pertussis organisms. The

tracheal smooth muscle response to carbachol was measured and compared

with that found in trachea from unvaccinated mice (n = 15). The

contractile response was similar in both groups. The tracheal smooth

muscle relaxant effects of isoproterenol were measured in these two

groups. The EC50 value for isoprenaline (6.5 x 10(-7) M) in trachea

from B. pertussis treated mice was significantly (P < 0.05) greater

than that noted in the control animals (2.3 x 10(-7) M). These studies

demonstrated that in tracheal smooth muscle isolated from B. pertussis

vaccinated mice, the relaxant effects of isoprenaline are impaired.

 

PMID: 6255813, UI: 81083817

 

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Agents Actions 1986 Dec;19(5-6):366-7 Disturbance of mice tracheal

beta-adrenoceptor and cholinergic receptor function by Bordetella

pertussis and its cell wall components.

 

Veenendaal GH, Kool DJ, de Wildt DJ, Nijkamp FP

 

PMID: 2881459, UI: 87152780

 

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Yale J Biol Med</em> 1968 Apr-Jun;40(5):507-21 Pertussis sensitization

as an animal model for the abnormal bronchial sensitivity of asthma. [***]

 

Reed CE PMID: 5673857, UI: 68400428

 

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Dermatol Clin 1990 Jan;8(1):161-4 Reactions to thimerosal in hepatitis

B vaccines. [***]

 

Rietschel RL, Adams RM Department of Dermatology, Ochsner Clinic,

New Orleans, Louisiana.

 

Hypersensitivity to thimerosal in vaccines has been reported to induce

persistent local reactions, urticarial and generalized exanthematic

eruptions, and, in the case of the hepatitis B vaccine, urticaria with

asthma. The authors describe two cases of extensive reactions, one

in a patient who did not form antibodies to the principal vaccine

antigen. Although not all thimerosal-sensitive patients develop

adverse reactions to vaccines containing this material, there is a

potential risk, and the reactions can be very long lasting.

 

PMID: 2137393, UI: 90150805

 

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West J Med 1987 Sep;147(3):341 Asthma and urticaria after hepatitis

B vaccination.

 

Lohiya G PMID: 2960084, UI: 88044753

 

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Science 1997 Jan 3;275(5296):41-2 Asthma: an epidemic in the absence

of infection?

 

Cookson WO, Moffatt MF University of Oxford, Nuffield

Department of Medicine, John Radcliffe Hospital, Oxford OX3 9DU,

UK. william.cookson@clinical-medicine.ox.ac.uk

 

Comment on: Science 1996 Jan 3;275(5296):77-9

 

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Salud Publica Mex 1974 Sep-Oct;16(5):707-20 Repercussions of

vaccination against measles.  [Article in Spanish]

 

Guerrero EV, Calderon C, Velazquez Franco E PMID: 4456647, UI: 75141084

 

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J Allergy Clin Immunol 1975 Mar;55(3):152-63 Humoral and cellular

immunity in asthma. [***]

 

Grove DI, Burston TO, Wellby ML, Ford RM, Forbes IJ

 

Parameters of humoral and cellular immunity have been measured in 91

asthmatic patients. Mean serum levels of IgG and IgE were raised. IgG

levels were higher in those with a family history of asthma. IgE

levels were higher in those with a past history of atopic eczema, but

intrinsic and extrinsic asthma could not be differentiated on the

basis of IgE levels. Thirteen of 74 patients failed to respond to

tetanus immunization, while only 1 failed to respond to Salmonella

typhi H antigen. Tetanus nonresponders had a raised mean serum IgA

level, reduced spontaneous lymphocyte tritiated thymidine uptake, and

reduced thymidine uptake in fetal calf serum. Eight of 87 patients

failed to mount delayed hypersensitivity reactions to a battery of five

intradermal antigens.  The tritiated thymidine uptake of lymphocytes

stimulated with phytohemagglutinin was normal in autologous serum,

but reduced in fetal calf serum. The data support the hypothesis that

asthma may be associated with immunodeficiency states.

 

PMID: 1089697, UI: 75096028

 

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Harefuah 1987 Jan 15;112(2):70-1 Allergic vasculitis and bronchial

asthma following influenza vaccination.  [Article in Hebrew] [***]

 

Reizis Z, Frank J, Sikuler E PMID: 3596383, UI: 87248326

 

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Allerg Immunol (Paris) 1987 Jan;19(1):18-21 Influenza vaccination

and asthma.  [Article in French] [***]

 

Migueres J, Sallerin F, Zayani R, Escamilla Service des Malades

Respiratoires, CHU de Rangueil, Toulouse.

 

A double investigation was carried out on the respiratory tolerance

of IV in the asthmatic patient: 1. Retrospective based on case history

in 87 mature adults (mean age 61 years) previously vaccinated once or

several times. This showed poor respiratory tolerance in 21 patients

(24%), as shown by difficulty in breathing (8 cases), paroxystic

dyspnea (5 cases), an acute episode of asthma (8 cases), occurring soon

after vaccination. 2. Clinical and respiratory functional prospective

study of bronchial reactivity to carbachol (CBL) and flow-volume

curves before and after administration of inactivated polyvalent

vaccine, compared in 8 control subjects, 12 asthmatic patients, 19

cases of non-spactic chronic obstructive airway disease, 7 patients

with sequelae of pulmonary tuberculosis or operated bronchial cancer,

investigated immediately before (day 0), 2, 6, 8 or in some cases 20

or 30 days after IV (D2, D6, D8, D20, D30): 2 of 8 controls showed a

decrease in CBL sensitivity threshold at D2 or D6; 6 of 12 asthmatics

reacted to the vaccine: 2 showed increased CBL reactivity, 1 lowered

sensitivity threshold, 2 a decrease in the 50% and 25% flows at D2

and D6, 1 decreased MMFR and distal flows at D2; 4 of 19 cases of

COPD, 1 of 7 cases of tuberculous sequelae showed various reactions

at D2, D6, D8.  PMID: 3454168, UI: 88293651

 

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J Pharmacol Exp Ther 1980 Dec;215(3):691-6 Effects of vaccination

with Haemophilus influenzae on adrenoceptor function of tracheal and

parenchymal strips.

 

Schreurs AJ, Terpstra GK, Raaijmakers JA, Nijkamp FP

 

Haemophilus influenzae is a bacterium that can be isolated from the

deeper airways of asthmatic patients. We investigated the effect

of vaccination with H. influenzae on alpha and beta adrenoceptor

function in guinea-pig tracheal spirals and lung parenchymal

strips. The tracheal spirals from H.  influenzae-vaccinated animals

showed significantly less relaxation to isoproterenol as compared to

controls, independent of whether the trachea was maximally contracted

with carbachol or only exhibited an intrinsic tone. Furthermore, an

increased contractile response to carbachol was observed in these

spirals. To isoproterenol in the presence of a beta-2 adrenergic

antagonist (H35/25), or to salbutamol alone, the tracheal preparations

from H. influenzae-vaccinated animals also showed a decreased

relaxation. These results suggest involvement of both beta-1 and

beta-2 subtype adrenoceptors. On the other hand, lung parenchymal

strips from vaccinated guinea-pigs relaxed significntly more to these

drugs. This effect was not influenced by H35/25 but could be inhibited

by phenoxybenzamine. Histamine-induced contraction did not differ

between the groups. These results indicated that H. influenzae causes

a partial blockade of the beta adrenoceptors in tracheal spirals and,

therefore, may have important implications in asthmatic bronchitis. In

contrast, parenchymal lung strips of the H. influenzae-pretreated

group showed an increased relaxation.

 

PMID: 6969303, UI: 81071818

 

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Lancet 1998 Jan 31;351(9099):326-31 Randomised placebo-controlled

crossover trial on effect of inactivated influenza vaccine on pulmonary

function in asthma. [***]

 

Nicholson KG, Nguyen-Van-Tam JS, Ahmed AH, Wiselka MJ, Leese J, Ayres

J, Campbell JH, Ebden P, Eiser NM, Hutchcroft BJ, Pearson JC, Willey

RF, Wolstenholme RJ, Woodhead MA

 

Department of Infectious Diseases and Tropical Medicine, Leicester

Royal Infirmary, UK.

 

BACKGROUND: Despite current recommendations, many people with asthma

do not receive annual vaccination against influenza, partly because

of concern that vaccine may trigger exacerbations. Colds can trigger

exacerbations, which may be mistaken for vaccine-related adverse

events. We undertook a double-blind placebo-controlled multicentre

crossover study to assess the safety of influenza vaccine in patients

with asthma, with allowance for the occurrence of colds. METHODS:

We studied 262 patients, aged 18-75 years, who recorded daily peak

expiratory flow (PEF), respiratory symptoms, medication, medical

consultations, and hospital admissions for 2 weeks before the first

injection and until 2 weeks after the second injection. Order of

injection (vaccine and placebo) was assigned randomly. There was an

interval of 2 weeks between injections. The main outcome measure was

an exacerbation of asthma within 72 h of injection (defined as a fall

in PEF of &gt;20%).  FINDINGS: Among 255 participants with paired data,

11 recorded a fall in PEF of more than 20% after vaccine compared with

three after placebo (McNemar's test p=0.06); a fall of more than 30%

was recorded by eight after vaccine compared with none after placebo

(binomial test p=0.008). However, when participants with colds were

excluded, there was no significant difference in the numbers with falls

of more than 20% between vaccine and placebo (six vs three; binomial

test p=0.51), although the difference for PEF decreases of more than

30% approached significance (five vs none; binomial test, p=0.06).

This association was confined to first-time vaccinees. INTERPRETATION:

Our findings indicate that pulmonary-function abnormalities may occur

as a complication of influenza vaccination. However, the risk of

pulmonary complications is very small and outweighed by the benefits

of vaccination.

 

PMID: 9652613, UI: 98314721

 

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Med J Aust 1990 Sep 17;153(6):367 Dangers of immunotherapy for the

treatment of asthma in children.

 

Phelan PD Comment in: Med J Aust 1990 Dec 3-17;153(11-12):744 Comment

in: Med J Aust 1991 Feb 18;154(4):294

 

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Wien Klin Wochenschr 1989 Aug 4;101(15):504-11 Comparative studies of

the effectiveness of specific immunotherapy in house dust mite allergy.

[Article in German]

 

Ebner H, Neuchrist C, Havelec L, Kraft D Ambulatorium fur Allegie

und klinische Immunologie, Wien.

 

In a prospective study, 60 patients with allergic rhinoconjunctivitis

and/or asthma due to house dust mites were chosen for hyposensitization

treatment with Migen (M) or Pharmalgen (P). Immunotherapy stretched

over a whole year and every 3 months clinical results were evaluated by

the patient's symptom score, by results of skin prick and conjunctival

provocation tests, as well as by RIA and ELISA regarding the total and

specific IgE and also specific IgG and IgG4 levels. Out of 30 patients

of the M group, 15 were followed up over the whole therapeutic regimen,

4 of whom showed a very good, 7 a good to moderate clinical outcome and

4 showed no improvement at all. In the P group, 17 out of 30 patients

were followed up whereby 9 showed a very good and 8 a good to moderate

response. In both groups of patients a statistically significant

decrease in skin and conjunctival sensitivity to mite allergens was

observed after 12 months of therapy. However, there was no correlation

between this observation and the failure or success of immunotherapy.

Furthermore, in both groups there was significant increase in total

and specific IgE (with a slight decrease after 6 to 12 months) and

also in specific IgG and IgG4 (especially in the P group), but again

these changes in antibody levels gave no indication of a good or bad

clinical outcome. Hence, we believe other reasons than the usually

presented thesis of inducing "blocking antibodies" by immunotherapy

to be responsible for the well-known effects of hyposensitization.

 

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J Allergy Clin Immunol 1985 Dec;76(6):773-5 What we do and do not

know about mold allergy and asthma.

 

Reed CE PMID: 4067126, UI: 86060482

 

 

 

 

   << All opinions expressed are mine, not the University's >>

 

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   David Foster    National Center for Microscopy and Imaging Research

    Programmer/Analyst     University of California, San Diego

    dfoster@ucsd.edu       Department of Neuroscience, Mail 0608

     http://ncmir.ucsd.edu/

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   "The reasonable man adapts himself to the world; the unreasonable one

   persists in trying to adapt the world to himself.  Therefore, all progress

   depends on the unreasonable."   -- George Bernard Shaw

 

 

ALL INFORMATION, DATA, AND MATERIAL CONTAINED, PRESENTED, OR PROVIDED HERE IS FOR GENERAL INFORMATION PURPOSES ONLY AND IS NOT TO BE CONSTRUED AS REFLECTING THE KNOWLEDGE OR OPINIONS OF THE PUBLISHER, AND IS NOT TO BE CONSTRUED OR INTENDED AS PROVIDING MEDICAL OR LEGAL ADVICE.  THE DECISION WHETHER OR NOT TO VACCINATE IS AN IMPORTANT AND COMPLEX ISSUE AND SHOULD BE MADE BY YOU, AND YOU ALONE, IN CONSULTATION WITH YOUR HEALTH CARE PROVIDER.
 

 

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